Partner 13: GATC Biotech GmbH (GATC), Constance, Germany
Headquartered in Constance, Germany, GATC Biotech has more than 150 employees and serves over 10,000 customers in 40 countries. The employees are mostly scientists with long-term experience in biotechnology, biochemistry and molecular biology. GATC Biotech has a R&D department fully dedicated to evaluate and implement newest technologies. GATC Biotech offers true multiplatform sequencing using all leading sequencing technologies in its own labs: Sanger Sequencing with a fleet of 16 ABI 3730xl, Next and Third Generation Sequencing using illumina and PacBio sequencing technology. GATC Biotech’s acknowledged bioinformatics solutions allow high-end data analysis for its customers in pharmaceutical, diagnostic, chemical and food industries as well as academia.
Partner 13 team leader:
GATC will describe the phenotype of humanised mouse models and iPSCs by transcriptomics and epigenomics analysis in WP8.2 and 8.3. Deep sequencing of the transcriptome will be accomplished using Illumina’s HiSeq 2500/4000 which enables the detection of sequence variants (SNPs, DIPs) with high accuracy. With state-of-the-art NGS technologies GATC will investigate cytosine methylation as well as histone modifications that are important regulators of gene expression.
GATC Biotech is Europe’s leading service provider of DNA sequencing. For over two decades the company has offered sequencing and bioinformatics solutions for individual samples, transcriptomes and regulomes, up to whole genomes. GATC Biotech has sequenced more than 5 million samples, thousands of bacterial, plant or other whole genomes as well as hundreds of whole human genomes for more than 10,000 academic and industrial customers worldwide. GATC´s subsidiary LifeCodexx emphasises the development of clinically validated molecular diagnostic tests and offers a risk-free alternative to common invasive examination methods such as amniocentesis.
Selected participations to European projects and Networks: EUROSFUN (FP6), CONSERT (FP6), XENOME (FP6), EURO-GENE-SCAN (FP6), PERSIST (FP7), CELL-PID (FP7), SysCLAD (FP7), EpiFemCare (FP7).
Specific awards and certifications: GATC Biotech is ISO 9001:2000 certified since 1997 and ISO/IEC 17025:2005 certified for Next Generation Sequencing since 2012. Certified Service Provider of Illumina Inc. and Pacific Biosciences Inc.; “Land of Ideas” award 2008 for GATCs idea of “NightXpress” night sequencing service.
1. Paprotka T, et al. (2012) Third Generation Sequencer: New possibilities for de novo assemblies (article in German) BIOspektrum Volume 18, Issue 5, pp 524-526.
2. O’Connell RJ et al. (2012) Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. Nat Genet.;44(9):1060-1065.
3. Bauser C, Kumar Y, (2012) Sequencing and analysis of micro-RNAs (article in German), BIOspektrum Volume 18, Issue 3, pp 294-296.
4. Frank S, et al. (2011) Pseudomonas putida KT2440 genome update by cDNA sequencing and microarray transcriptomics. Environ Microbiol. doi: 10.1111/j.1462-2920.2011.02430.
5. Morgenstern D, et al. (2011) The tale of a resting gland: Transcriptome of a replete venom gland from the scorpion Hottentotta judaicus. Toxicon. 57(5):695-703.
6. Coste AT et al. (2009) Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system. Eukaryot Cell. 8(8):1250-67.
7. Ferrari S, et al. (2009) Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence. PLoS Pathog. 5(1).
8. Stangier K, (2008) Next-Gen Sequence Analysis and Utility, Drawbacks & Opportunities. ChemManager: 14-16 [Overview article on Next Generation DNA Sequencing Technologies and their applications].